- Jun 12, 2022
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I am so sorry to hear of your loss. So many people suffered so badly (and are still suffering) as a result of the extended insanity felt the world over during the last three years. I lost both friends and family members, though not to the virus itself.If the general population could think critically, ivermectin is an excellent and safe parasitic, but that does not make it a safe and effective antiviral. My uncle believed the hype, decided since the media demonized it it was safe to treat his complicated covid case. Sadly, since he chose that treatment over targeted treatment, he did pass away from covid complications. Not from ivermectin use. But because he did not take the recomme ded antivirals believing the iver would save him.
We have to be able to make these distinctions. I only share in hopes it might help someone.
But to be clear, ivermectin has actually been shown over the last decade to be an effective antiviral. In vitro and/or in vivo trials have indicated that it combats yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, dengue virus, West Nile virus, Venezuelan equine encephalitis virus, and the DNA virus pseudorabies virus:
- Mastrangelo E. et al. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. J. Antimicrob. Chemother. 2012; 67: 1884-1894
- Wagstaff K.M. et al. Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus. Biochem. J. 2012; 443: 851-856
- Lundberg L. et al. Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan equine encephalitis virus replication. Antivir. Res. 2013; 100: 662-672
- Lv C. et al. Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and in vivo. Antivir. Res. 2018; 159: 55-62
Yes, we need to think critically, but if we don't have facts or trustworthy evidence, that's nearly impossible to do. Unfortunately, given the spin on both sides, it's difficult to fund, perform, publish, or even recognize valid studies on the subject of ivermectin and coronaviruses, so it's pretty hard to confidently say what it does for COVID-19. Many of us have seen multiple cases of anecdotal evidence that ivermectin is effective in treating the SARS-CoV-2 virus. That doesn't mean it's appropriate for all cases, or that it can be used as a single treatment (which is not generally recommended anyway), and complicated cases are all the more difficult. But some of the COVID-19 treatments recommended by medical authorities actually ended up damaging or killing patients (Remdesivir and ventilators, for example), so retaining ivermectin as a possibility in an array of treatment options makes sense to a lot of us.
I wish that the wider scientific and medical community was as open to critical discussion as the folks on this forum!