Parasites must come from somewhere; they do not spontaneously appear.
Up to 6 months?!? Yowch! Do you have sources, so I can look into this further? I just told someone that they had to wait 30 days after ivermectin before butchering a rabbit, and I'm horrified that this somewhat common knowledge may be that wrong! I certainly don't want to mislead anyone about ivermectin in meat rabbits.ladysown":2g0pa4be said:NOT ivermectin as it stays with rabbits I've learned up to six months!
After 10 half-lives, only .1% would remain. 10 half-lives for ivermectin would be 12 days (using the 28-hour measurement), and for the metabolites would be 30 days.Half-life:
22 to 28 hours; however, some reports have shown a half-life of 12 to 16 hours for ivermectin and 3 days for its metabolites.
Doubling the dose of medication requires only one more half-life to bring it to the same concentration as a regular dose.quote from Basic Clinical Pharmacology by Michael Winter:
"The time required for a drug concentration to reach steady state is determined by the drug's half-life. It takes one half-life to reach 50%, 2 half-lives to reach 75%, 3 half-lives to reach 87.5%, 3.3 half-lives to reach 90%, and 4 half-lives to reach 93.75% of steady state....In most clinical situations, the attainment of steady state can be assumed after 3-5 half-lives."
The same numbers 3-5 half-lives are used to calculate the elimination of the drug.
If we take Klonopin's longest half-life number, which is 50 hours, that would be 50hours x 5 = 250 hours = 10.42 days. So it takes around 10 days for Klonopin to build to full strength is the blood stream and likewise it takes about that time for the drug to be eliminated.
In the case of valium, the longest half-life is 200 hours. So full strength is achieved after 200hours X 5 = 1000hours = 41.66 days.
Note that build up and elimination of all drugs can be calculated in the same way. http://www.benzosupport.org/drug_half-life.htm
While it doesn't come right out and say, "a drug is considered gone from the meat of an animal after 10 half-lives", it does seem to be saying that. It does note that the half-life will be longer in an animal that is sick enough for its biological processes to slow down.In 10 half-life periods, 99.9% of the drug residue will have been eliminated from the animal. If the half-life of a particular drug is 3 hours, almost all of the drug will have been eliminated by 30 hours after administration. If the half-life is 3 days, then it will take 30 days for a similar reduction. Thus, doubling the dose of drug given should only extend the time by one half-life to achieve near compete removal from the body.
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