Thank you that is very helpful.
Pyrrolizidine alkaloids: Plants containing pyrrolizidine alkaloids (PAs) are found throughout the
world. PA poisoning is of great economic importance as a cause of progressive liver disease in
livestock, wildlife and humans. The disease has been reported from most areas of North America
and is mostly caused by plants from the genus Senecio, but other plant genera such as Amsinckia,
Cynoglossum, Echium and Heliotropium also contain the toxic alkaloids. Within the Senecio
genus, Senecio vulgaris (common groundsel) and Senecio jacobaea (tansy ragwort) are common
weeds in hayfields in California and are also widely distributed along the East Coast and Canada.
PA-containing plants are usually unpalatable and animals avoid them. However, animals are
often not able to differentiate the toxic weeds in hay and ingest the toxic alkaloids. PAs are
hepatotoxic, causing irreversible liver damage (Cheeke, 1998). Horses and cattle are the major
livestock species poisoned by PAs. Sheep, goats and small herbivores (e.g. rabbits, guinea pigs,
hamsters) are resistant to PA toxicity due to detoxification processes in the liver (Cheeke, 1994).
PA poisoning is usually a chronic disease and clinical signs may not appear for 2-8 months after
the first ingestion of the toxic plants. Affected animals lose condition, and develop icterus. Cattle
may also develop photosensitization. Neurological signs are commonly seen in horses, and the
Cheeke PR: 1994, A review of the functional and evolutionary roles of the liver in the
detoxification of poisonous plants, with special reference to pyrrolizidine alkaloids. Vet Hum
Toxicol 36:240-247.
the reluctant farmer":2yg9msit said:In the area I grew up in it was regularly used by the Polish & Russian immigrants who had migrated there, and it rapidly spread from small homesteads to becoming invasive with the use of industrial tilling methods. My understanding was that it was used by the old settlers as a medicine by poultice or through tea/tonic and also as an animal food. I'd suspect that either the toxicity reports come from large amounts or if it is eaten in isolation. Possibly they were eating other things alongside it that balanced out any accumulation. I think Rainey's approach makes sense, and I intend to be feeding it this year since I have some plants my mom dug up and gifted me with. Will check out how my meat mutts do with it...
Hepatotoxicity
Several cases of acute liver injury resembling sinusoidal obstruction syndrome due to oral comfrey have been published. The injury usually arises within 1 to 2 months of starting the comfrey product (either extract in tablet form or large amounts of comfrey tea)
michaels4gardens":2hnnwgzi said:I still toss some in with the rest of the weeds and kale, -- but-- I do not keep track of how much they eat.-- I just let them eat what ever they want , and the next night before I feed,- I toss the rest to the chickens, and sheep [caution, -young sheep can choke on comfrey, it sticks to their tongue like velcro, and can block the airway ]alforddm":2hnnwgzi said:Do you still feed comfrey? So, according to your observations an amount up to 25% of the diet can be beneficial?michaels4gardens":2hnnwgzi said:I have done some research on feeding comfrey, -when more then 35% of the diet was comfrey, I began to see lighter spots on the livers, and slight yellowing of the liver,[at 8 week butchering] and the growing rabbits slowed down on growth rate. I fed 25% as a part of the ration for 3 years, and saw a good increase in growth rate over the litters that did not get it. I saw no problems with the breed stock at all [but did not kill any of them to look] the greatest advantage was when the kits were still nursing, --it seems to me- does produce more milk when fed comfrey.
ottersatin":31eww9ps said:This is a very interesting thread!
I have been feeding small occasional amounts of Comfrey to my Rabbits
for just about as long as can remember having it. It seems to me that they
are very fond of the few [one or two] leaves I give them every now and then.
I believe that everything, if fed in moderation has it's place.
Every medication that WE take IS a POISON! This is why the amounts,
and length of time taking it/them is specified.
I have my Comfrey planted where I can keep it under control.
Left to it's own it can become a growers problem, it can spread very quickly.
Ottersatin. ldtimer:
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