Inbreeding and line breeding are wonderful tools that you can use to fix type in your stock. By 'fix' I don't mean repair, I mean solidify.
You don't create problems with in/line breeding, the practice only shows you what you already may have hidden in your genetics. If you have lots of problems, doubling up on them may magnify them.
However, as a tool used to double up on things you want in your lines, in/line breeding is the practice you will want to use. It is how the breeds we have today were created.
It may lead to great problems, but also great rewards in a breeding program.
Mother/son and father/daughter gives you more control in your output. 50% of the genetics come from each parent, so in this type of breeding you know you will be doubling up on the parent's genes and half from the offspring in the kits.
Sibling breedings are more random. If the offspring get all the genetic material from one grandparent through the parents you would have 100% genetic material from that grandparent. However, if the offspring received half of its genetics from one grandparent and half from the other, the resulting kit would be genetically similar to another offspring of the original two parents. Of course you could have any % in between as well, and you would never know. There is less control in this type of breeding. It is far more random.
For example, I have a litter from a pair of normal furred siblings. The normal furred siblings I bred have a satin dam and a normal furred sire. 8 kits were born. Only one of those kits got the satin gene from each parent and has satin fur. The other 7 have normal fur and I have no idea if any are carrying a satin gene or not. If I had bred the satin grand dam to her normal furred son, I would have had a higher chance of getting satin fur AND I would know that all the normal furred kits would be carrying one copy of the satin gene. More control in this breeding.
Clear as mud?