I had one doe who got annoyed with her kits around 6 weeks. You could tell. She would try to get in a corner as far from them as possible. Most does, however, don't mind having them around until at least 8 weeks. These does are usually stretched out, relaxed, with kits climbing over them, and still sleeping away. Some people take the biggest two or three out first for a week, and then remove the smaller ones. I generally just take them all out at 7-8 weeks.