Large breeds should be fine and probably dutch or minis but I'd watch them. I had some netherlands climb 3' when they were hardly out of the box and possibly still small enough to fit through wire. They climbed out of a cage made of 1/4x1/4" hardware cloth that I hadn't put a roof on yet. I figured the several feet in height was good enough. Unfortunately I also had a checkered giant in the colony underneath that killed all small rabbits and every kit that landed on the ground was dead. Some did land on a section of the frame sticking out from under the cages and were recovered.